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	Provedor de dados BJMBR (2) Genet. Mol. Biol. (1) Autor Li,Jin (3) Jiang,Lifeng (2) Yang,Haoyu (2) Zhou,Xindie (2) Chen,Gang (1) Dong,Zai-Quan (1) He,Jin (1) Jiang,Xijia (1) Kuang,Wei-Hong (1) Tian,Lian-Tian (1) Wu,Lidong (1) Xu,Nanwei (1) Xu,Zhonghua (1) Mais... Palavra-chave Single-nucleotide polymorphism (2) ACE4 (1) AIRE (1) Bioinformatics analysis (1) Case-control study (1) Depression (1) Hamilton Depression Scale (1) MicroRNA-221-3p (1) MicroRNA-34a-5p (1) MicroRNA-451a (1) Osteoarthritis (1) Paroxetine (1) Rheumatoid arthritis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2020 (1) 2018 (2) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última A functional polymorphism in the paired basic amino acid-cleaving enzyme 4 gene confers osteoarthritis risk in a population of Eastern China Genet. Mol. Biol. He,Jin; Yang,Haoyu; Xu,Zhonghua; Li,Jin; Chen,Gang; Jiang,Lifeng; Wu,Lidong; Zhou,Xindie. Abstract Paired basic amino acid-cleaving enzyme 4 (PACE4), a proprotein convertase, is involved in the activation of aggrecanases (ADAMTS-4 and ADAMTS-5) in osteoarthritic and cytokine-stimulated cartilage. Activated aggrecanases cause aggrecan degradation and thus, contribute to osteoarthritis (OA). In this study, we investigated the association between PACE4 gene polymorphisms and OA risk. One single-nucleotide polymorphism (rs4965833) in the PACE4 gene was genotyped in 432 OA patients and 523 healthy controls using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Quantitative reverse transcription PCR (qRT-PCR) was used to determine the relative expression of PACE4 in blood samples from 90 OA patients (30 for each... Tipo: Info:eu-repo/semantics/article Palavras-chave: ACE4; Osteoarthritis; Bioinformatics analysis; Single-nucleotide polymorphism. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000100104 MicroRNA-451a, microRNA-34a-5p, and microRNA-221-3p as predictors of response to antidepressant treatment BJMBR Kuang,Wei-Hong; Dong,Zai-Quan; Tian,Lian-Tian; Li,Jin. Aberrant expression of microRNAs (miRNAs) has been shown to be involved in early observations of depression. The aim of this study was to determine if serum levels of miRNA-451a, miRNA-34a-5p, and miRNA-221-3p can serve as indicators of disease progression or therapeutic efficacy in depression. We collected data from 84 depressed patients and 78 control volunteers recruited from the medical staff at the West China Hospital. Depression severity was rated using the 24-item Hamilton Depression Scale (HAMD). Serum miRNA-451a, miRNA-34a-5p, and miRNA-221-3p levels were determined in samples from the depressed patients before and 8 weeks after antidepressant treatment as well as in samples from controls. Compared with the controls, the patients had lower... Tipo: Info:eu-repo/semantics/article Palavras-chave: MicroRNA-451a; MicroRNA-34a-5p; MicroRNA-221-3p; Depression; Hamilton Depression Scale; Paroxetine. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000700609 The rs878081 polymorphism of AIRE gene increases the risk of rheumatoid arthritis in a Chinese Han population: a case-control study BJMBR Yang,Haoyu; Li,Jin; Jiang,Lifeng; Jiang,Xijia; Zhou,Xindie; Xu,Nanwei. The autoimmune regulator (AIRE), a transcriptional regulator expressed in medullary thymic epithelial cells, plays an important role in thymocyte education and negative selection. Several citations studying the association between the rs878081 exon polymorphism of the AIRE gene and the risk of rheumatoid arthritis (RA) in different populations have yielded conflicting findings. Thus, this case-control study involving 300 RA cases and 300 controls was aimed to identify whether such association existed in a Chinese Han population from East China. The rs878081 polymorphism of the AIRE gene was genotyped. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using the chi-squared test, genetic model analysis, and stratification analysis. Genetic... Tipo: Info:eu-repo/semantics/article Palavras-chave: AIRE; Single-nucleotide polymorphism; Rheumatoid arthritis; Case-control study. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200612 Registros recuperados: 3 Primeira ... 1 ... Última

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